Imagine walking into a doctor’s office or mobile clinic for a disease screening, breathing a few breaths into a breath-collection bag, and getting your results within ten minutes. This is the promise of Exhalent Diagnostics’ revolutionary disease-screening platform: Rapid and non-invasive disease diagnosis at the point-of-care, or wherever you need it, to improve treatment outcomes, limit the spread of disease, and save lives.
Exhalent Diagnostics’ breakthrough sensors are made of self-organizing titanium dioxide nanotube arrays. The sensors can be structured—by varying the length, diameter, and wall thickness of the nanotubes—to detect specific molecules, including biomarkers associated with a variety of diseases. When target molecules are present, they react with the nanotubes and create a measurable electrical response.
Biomarkers, measurable indicators of a biological process, can be used to assess the risk or progression of a disease. Volatile organic compounds (VOCs) in breath can act as biomarkers for a variety of diseases, including cancers, diabetes, and infectious diseases. But, measuring VOCs in breath is difficult. VOCs are often present in extremely small quantities and they degrade very quickly. The equipment required to sense them is expensive and cumbersome, making clinical use infeasible. Indeed, there is to date no clinically approved application to diagnose disease using breath-based biomarkers. Our revolutionary sensing technology will change that.
In lab tests published in peer-reviewed scientific journals [1,2,3,4,5], as well as in an unpublished 600 patient field study, our sensors successfully detect four unique breath-based biomarkers produced by an active tuberculosis (TB) infection. After validating our platform by developing a screening test for TB, we intend to pursue other important potential applications, including promising tests for colorectal cancer and pneumonia, among others.
If you are interested in using our sensor to detect other biomarkers or molecules, please contact us.
Our device is easy-to-use and designed so that healthcare workers—ranging from physicians to medical assistants—can easily administer screening tests at the point-of-care or wherever needed. The process is simple: A patient fills a breath collection bag with a few exhaled breaths, and the care-giver connects the bag to a sensor unit. A pump automatically passes the exhaled breath across the sensor. Target biomarkers for a disease, if present, bind to the sensor and generate a measurable electrical response, which is then communicated to a tablet or smartphone. Our app, using a proprietary algorithm, provides results in less than ten minutes. The breath bag with the sensor is then discarded and a new one used for the next test.
*Investigational device. Limited by US law to investigational use.
DR. DANIEL OLSON
CHIEF EXECUTIVE OFFICER
Daniel is passionate about entrepreneurship. He has spent more than fifteen years working with startups and entrepreneurs—as an entrepreneur himself, a professor of entrepreneurship, a consultant to startups, and a corporate and venture capital lawyer. He is currently an Assistant Professor at the University of Washington’s Foster School of Business teaching courses in entrepreneurship and business strategy. Daniel received his Ph.D. in Strategy and Entrepreneurship from the Smith School of Business at the University of Maryland, College Park, his J.D. from Harvard Law School, and his B.A. from Brigham Young University.
DR. JASON YOUNG
PRESIDENT AND CHIEF MEDICAL OFFICER
Jason cares about improving the lives of those around him, although he does it through entrepreneurship rather than attending to individual patients. While in medical school, he saw firsthand the impact of innovative technologies on the lives of his patients. After medical school, he decided to combine his knowledge of medicine with his skills and experience in business to help startups commercialize these technologies. He brings his expertise—including interfacing with medical care providers, developing relationships with key partners, managing field studies and clinical trials, and implementing innovative business models—to Exhalent Diagnostics. Jason received his M.D. from the University of Utah and his M.B.A. from the University of Notre Dame.
CHIEF OPERATING OFFICER
Blain knows how to build and sell products and companies. He is an experienced materials science engineer and entrepreneur. He has more than twelve years of experience working as an engineer for industry leading firms including Ecolab, FLSmidth, Freeport McMoRan, and Barrick Gold. He founded and served for five years as the CEO of Material Solutions, Inc., a company that produced TiH2 and other titanium alloys. He was also the production and maintenance manager of Chappell Cheese for over ten years. Blain received a B.S. in materials science and engineering from the University of Arizona, where he earned college of engineering honors for outstanding achievement.
CHIEF FINANCIAL OFFICER
Gordon is a money man. He knows how much money we have, how much money we need, what we are spending it on, and what we need to spend it on. He has more than twenty years of accounting experience in both large and small businesses in a variety of industries. He brings to Exhalent Diagnostics his experience directing all company accounting and financial functions, including treasury, payroll, cash flow statements, budgets, forecasting, and analysis. Gordon received his M.B.A. from the University of Phoenix and his B.S. in accounting and business management from Utah Valley University.